INSULIN ORAL DELIVERY: SYNERGISTIC EFFECT OF AZONE, BACITRACIN, AND GOLD NANOPARTICLE

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SEUNG MIN OH
JIHUN HAN
YU JIN CHO
ANTHONY W. BAE
GI WON SUNG
HAE SEOK YOON
KAREN JANG
ANDREW HWANG
SERIN AHN
TAEHYUK KIM
YOUNGIL CHUNG
ESTHER NAM
JONGBIN LEE

Abstract

Oral insulin follows the physiology of endogenous insulin secreted in pancreas. Intestinal absorption of oral insulin assist its uptake into blood stream and subsequently into the liver at the concentration of blood glucose reduction via the portal vein. Still, various transport barriers dwarf the insulin bio availabilty when administered orally. Therefore, systematic approach of oral insulin formulation has been required. To overcome these transport barriers, an improved formulation of insulin with various excipients was investigated, while being adminitered orally using gradual combinations of the gold nanoparticle, azone, and bacitracin in a rodent experimental model.  The objective of the study was to examine the enhancing profiles of insulin uptake while adding the excipients in a step-wise manner.


Experimental results with pharmacodynamic parameters demonstrated that there existed a synergistic effect additively when evaluated in BG change% and AUC. The maximal BG% decrease and AUC with respect to adding ingredients showed a high linearity with the step-wise addition of each composition (R2>0.90).  The result led us to draw a conclusion that the addition of the excipients into the oral insulin formulations induced a synergistic increase in BG drop.

Keywords:
Oral insulin, alternate delivery, protein and peptide drugs, pharmacodynamic analysis, penetration promoters, enzyme inhibitors

Article Details

How to Cite
OH, S. M., HAN, J., CHO, Y. J., BAE, A. W., SUNG, G. W., YOON, H. S., JANG, K., HWANG, A., AHN, S., KIM, T., CHUNG, Y., NAM, E., & LEE, J. (2019). INSULIN ORAL DELIVERY: SYNERGISTIC EFFECT OF AZONE, BACITRACIN, AND GOLD NANOPARTICLE. Journal of Medicine and Health Research, 3(2), 57-66. Retrieved from http://ikpress.org/index.php/JOMAHR/article/view/4385
Section
Original Research Article