CYSTIC FIBROSIS: AN OVERVIEW WITH THE IMPACT OF GENE TECHNOLOGY

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SHREE RAM LAMICHHANE
NICOLE BLAKE
AMRIT BHANDARI
NEERAJ BHANDARI
NATALIE MILIC

Abstract

Cystic Fibrosis is an autosomal recessive disorder with no cure. It is one of the most common life-shortening genetic diseases in the Caucasian population, affecting more than 75000 individuals worldwide. This inherited multi-organ disease is associated with chronic lung infection, malabsorption, salt loss syndrome, infertility and numerous other comorbidities. Understanding the cystic fibrosis transmembrane conductance regulator (CFTR) gene mutation and function of CFTR protein has offered personalized treatment strategies to help those with CF. From in-vitro and in-vivo studies to pre-clinical and clinical trials, therapeutic drugs are finally having an impact, yet there are many more specific treatments under clinical investigation. This article summarizes the ongoing advances and technology in understanding the treatment of CF from more than two decades.

Keywords:
Cystic fibrosis (CF), CFTR gene, lung disease, GENE therapy, vectors.

Article Details

How to Cite
LAMICHHANE, S., BLAKE, N., BHANDARI, A., BHANDARI, N., & MILIC, N. (2018). CYSTIC FIBROSIS: AN OVERVIEW WITH THE IMPACT OF GENE TECHNOLOGY. Asian Journal of Research in Biology, 1(1), 1-12. Retrieved from http://ikpress.org/index.php/AJRiB/article/view/3322
Section
Review Papers